Автор: Tapash K. Ghosh and William R. Pfister
Название: Drug Delivery to the Oral Cavity: Molecules to Market
Издательство: CRC Press
Год: 2005
ISBN: 978-0824782931
Серия: Drugs and the Pharmaceutical Sciences (Book 145)
Язык: English
Формат: pdf
Размер: 15,1 mb
Страниц: 448
The oral cavity (OC) and its highly permeable mucosal tissues have been taken advantage of for decades as a site of absorption for delivery of drugs to the systemic circulation (oral transmucosal delivery, OTD), and for local delivery to the subjacent tissues (oral mucosal delivery, OMD). Administration of an active agent in a dosage form intended to release the drug in the oral cavity is referred to herein as an intraoral delivery system or intraoral dosage form (IOD). Intraoral delivery may provide for a local effect (i.e., breath freshening), absorption via the oral mucosal tissues for either a local drug effect (i.e., analgesia) or systemic drug effect (i.e., smoking cessation), or, with most drugs, provide for systemic absorption along the segments of the gastrointestinal tract (GIT).
The purpose of this book is to bring into perspective the practical and applied aspects of pharmaceutical development of new solid-state dosage forms for OTD and OMD systems, and the strategies that have been employed for effective systemic and local drug delivery to the oral mucosa.