Автор: Simon Benita
Название: Microencapsulation: Methods and Industrial Applications, 2nd Edition
Издательство: CRC Press
Год: 2005
ISBN: 9780824723170 / 0824723171
Серия: Drugs and the Pharmaceutical Sciences (Book 158)
Язык: English
Формат: pdf
Размер: 10,9 mb
Страниц: 784
Research, development, and sales of drug-delivery systems are increasing at a rapid pace throughout the world. This worldwide trend will intensify in the next decade as cuts in public health expenses demand lower costs and higher efficacy. To meet this demand, many efficient drugs currently in use will be reformulated within delivery systems that can be value-added for optimal molecular activity. In addition to the health sector, the cosmetic, agricultural, chemical, and food industries operate in an open marketplace where free and aggressive competition demands novel coating techniques with enhanced effectiveness at the lowest possible cost. Currently, microencapsulation techniques are most widely used in the development and production of improved drug- and food-delivery systems. These techniques frequently result in products containing numerous variably coated particles. The exact number of particles needed to form a single administered dose varies as a function of the final particle size and can lie in either the micro- or nanometer size range for micro- and nanoparticulate delivery systems, respectively.
Experts are now recommending that pharmaceutical companies move from the blockbuster model to a more extensive product portfolio model that focuses on diseases with insufficient therapies mainly in specific populations such as the aging population. Furthermore, investigators are attempting to reformulate and add new indications to existing blockbuster drugs to maintain a reasonable scientific and economic growth rate.
Completely revised and expanded to represent the most up-to-date studies in the field, this guide covers advances in pulsatile delivery systems, injectable microparticulate systems, and site-specific delivery systems, as well as potential therapeutic applications of nanotechnology.