Автор: Mark Rogge and David R. Taft
Название: Preclinical Drug Development, 2nd Edition
Издательство: CRC Press
Год: 2009
ISBN: 9781420084726; 1420084720
Серия: Drugs and the Pharmaceutical Sciences (Book 187)
Язык: English
Формат: pdf
Размер: 10,4 mb
Страниц: 376
Topics range from assessment of pharmacology and toxicology to industry trends and regulatory expectations to requirements that support clinical trials. Highlights of the Second Edition include:
- Pharmacokinetics
- Modeling and simulation
- Formulation and routes of administration
- Toxicity evaluations
- The assessment of drug absorption and metabolism
- Interspecies scaling
- Lead molecule selection and optimization via profiling
- Screening using in silico and in vitro toxicity evaluations
The book also includes case studies on preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development, a review of ICH preclinical guidelines, and experimental methods used to study membrane drug transport and metabolism. This guide is a fundamental resource for medicinal chemists, biologists, and other specialists in the drug development sciences.