Название: Translational Toxicology and Therapeutics: Windows of Developmental Susceptibility in Reproduction and Cancer
Автор: Waters M., Hughes C.
Издательство: Wiley
Год: 2018
ISBN: 978-1-119-02360-9
Формат: PDF
Страниц: 774
Размер: 13.7 Mb
Язык: English
Translational biomedical research seeks to move laboratory findings based on
models (in silico, in vitro, and in vivo) into human clinical trials to more
expeditiously develop specific therapeutics, and then back again to the laboratory
to inform future discovery [1]. From the background of developmental
toxicology, it is well known that toxicant exposures may affect critical events in
reproductive development, ranging from early primordial germ cell determination
to gonadal differentiation, gametogenesis, external genitalia, or signaling
events regulating sexual behavior. Translational genetic toxicology takes advantage
of this developmental perspective to assess potential germ line mutagenesis
or to study the potential for cancer in the fetus or offspring or the adult as the
result of environmental exposures. Translational toxicology must strive to
identify applicable therapeutics that can safely and effectively identify and
help to mitigate potential harm from natural as well as anthropogenic environmental
exposures.